Production of Crosslinked Sodium Carboxymethyl Cellulose. Cross-Linked CMC Manufacturing Industry. Cross-Linked Sodium Carboxymethyl Cellulose Manufacturing Project.

Croscarmellose Sodium or Modified Cellulose Gum

Cross-linked sodium carboxymethyl cellulose is also known as croscarmellose sodium or modified cellulose gum. Cross-linked sodium carboxymethyl cellulose is semi synthetic polysaccharide that consists of glucose monomer chains which form a major component of plant cell walls and fibres. Crosslinked sodium carboxymethylcellulose (CMC), croscarmellose, is prepared by the reaction of Na-CMC with acids. Croscarmellose is used as dietary supplements, sweetener tablets, and medicines. The chapter provides nutritional properties of crosslinked sodium CMC.

Cross-linked sodium carboxymethyl cellulose is manufactured by acidifying an aqueous suspension of sodium carboxymethyl cellulose and heating the suspension to achieve cross-linking. The product is then washed and dried. It is also produced during the manufacture of sodium carboxymethyl cellulose by lowering the pH and heating to cause cross-linking. Cross-linked sodium carboxymethyl cellulose is used in tablets of table-top sweeteners and dietary food supplements, as it facilitates disintegration in aqueous solutions, with a maximum level of use of 30 g/kg. It is also widely used as an excipient in pharmaceutical applications.

Uses:

Cross-linked sodium carboxymethyl cellulose is used in tablets of table-top sweeteners and dietary food supplements, as it facilitates disintegration in aqueous solutions, with a maximum level of use of 30 g/kg. It is also widely used as an excipient in pharmaceutical applications.

Cross-linked sodium carboxymethyl cellulose is used in food as an emulsifier to maintain a uniform mixture between two or more unblendablemixutres. A mixture of oil and water. Used in many products including pasteurised products, ice-creams, cheeses, dairy products, batters, baked emulsions and spreads, breakfast cereals, and bakery goods.

Cross-linked CMC hydrogel proves to be an ideal agent for soft tissue augmentation with regard to safety and ease of application. It did not cause infection, extrusion, migration, or adverse reactions in the patients who have been followed for two years. Delayed aesthetic results on facial wrinkles were very satisfactory.

Cross-linked sodium carboxymethyl cellulose was originally developed as a tablet disintegrant for medicinal products and dietary food supplements, allowing dissolution at low use levels (0.25-3.0%). It has an official monograph in the European Pharmacopoeia. In the USA, it is used as a disintegrant in prescription drugs and has generally recognized as safe (GRAS) status for use in dietary supplements.

Few Indian major players are as under

·         Hexone Pharmaceuticals Ltd.

·         Hiranya Chemicals Pvt. Ltd.

·         Maple Biotech Pvt. Ltd.

·         Perry Impex Ltd.

·         Rishi Trading Co. Ltd.

·         Shreejal Info Hubs Ltd.

Market Outlook

The growth of processed food industry, increasing pharmaceutical and cosmetics production, and the growing oil drilling activities are the major factors driving the growth of CMC market. The increasing disposable income in emerging economies such as China, India, Mexico, Africa and South America has led to increasing consumption of processed food. CMC is widely used as binder, thickener, bulking agent, and suspension agent in several food and beverages applications. The segment accounted for a share of 31.0% of the global CMC market, in terms of volume consumed in 2014. The major factor restraining the CMC market growth is the emergence of substitutes in various applications. Guar gum can substitute in CMC in majority of the applications. The organic/green label associated with guar gum is an added advantage for the product to replace CMC in several applications.

The global carboxymethyl cellulose (CMC) market was estimated at $1,151.7 Million in 2014 and is projected to register a CAGR of 4.2% between 2015 and 2020.

Carboxymethyl cellulose (CMC) or cellulose gum is a cellulose derivative with carboxymethyl group in its chain. CMC is physiologically inert, chemically stable, odorless and tasteless substance which safe for health and environment. The other properties of CMC include high viscosity, non-toxic nature, and hypoallergenic. Major raw materials used in manufacture of carboxymethyl cellulose (CMC) include plant derived cellulose, caustic soda, and monochloroacetic acid. CMC is widely used as thickener, stabilizer, binder and dispersant in variety of applications such as food and beverages, pharmaceutical and cosmetics, detergents, oil and gas, paper processing and others.

Carboxymethyl cellulose can be defined as an additive used for improving product and processing characteristics in various fields, such as pharmaceuticals and food processing industry. Carboxymethyl cellulose is often used in forms such as sodium salt, sodium carboxymethyl cellulose. Sodium carboxymethyl cellulose is also used as a viscosity modifier or thickener, and to stabilize emulsions in various products including consumer goods and other major end-use industries.

Geographically Asia-Pacific dominated sodium carboxymethyl cellulose market driven in terms of production and consumption driven by higher demand into major end use industry in the region. Asia-Pacific was followed by North America and Europe as second and third largest market for sodium carboxymethyl cellulose market. Asia Pacific is projected to have fastest growth, owing to rapidly increasing and expanding industrial base leading to higher demand of sodium carboxymethyl cellulose.

Carboxymethyl cellulose is also popular for its excellent water retaining capacity amongst the major end-use industries apart from this other properties which makes sodium carboxymethyl cellulose more popular are resistant to oils, greases, and organic solvents. Sodium carboxymethyl cellulose is synthesized by the reaction of chloroacetic acid with cellulose.

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